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University of Pennsylvania Medical Center
Targeting inflammation within the tumor microenvironment for cancer therapy
Inflammation is a key determinant of cancer progression. Dr. Beatty’s research uses a mouse model of cancer that faithfully reproduces inflammation within the tumor microenvironment as is seen in human cancers. Using this model, he has found that macrophages linked to cancer can be therapeutically targeted and converted from tumor-promoting to tumor-suppressing. With the support of the Gabrielle’s Angel Foundation, this proposal will investigate the role of pro-inflammatory cytokines in regulating the phenotype of tumor-infiltrating macrophages. Findings will have direct implication for the design of therapies aimed at harnessing inflammation for cancer therapy.