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Johns Hopkins, Sidney Kimmel Comprehensive Cancer Center
Hedgehog signaling as a stem cell based therapeutic target in myelodysplastic syndrome and acute myeloid leukemia.
In many ways the growth of cancer mirrors the formation of normal organs during embryonic development. Dr. Matsui has found that a specific pathway required during development called the Hedgehog signaling pathway is abnormally turned on in acute myeloid leukemia and myelodysplastic syndrome. His lab will study the Hedgehog pathway in these diseases and test whether inhibitors of this pathway have anti-leukemic activity.