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University of Maryland School of Medicine
Identification of microRNAs that can inhibit T-cell acute lymphoblastic leukemia (T-ALL) cell survival and proliferation
Leukemia cells exhibit altered growth requirements. Using a functional screening approach, we will identify microRNAs that inhibit growth of T-ALL cell lines as a method to discern which microRNAs have potential therapeutic value. Analysis of microRNA targets will elucidate intracellular signaling pathways critical for T-ALL cell survival and proliferation.