Jeroen Roose, Ph.D.


University of California San Francisco
Therapeutic targeting of the oncogenic Ras pathway in T cell leukemia

My research group at UCSF focuses on understanding the biochemical signals inside the cell as they occur in developing cells that divide and differentiate. In parallel, we study how cancer cells have abnormal signals, what the composition is of these signals, and how these underlie the process of tumor formation. We use several cellular systems to study, notably normal T lymphocytes and their cancer-variant: T cell leukemia. The goal is to uncover sufficient insight into these signals so that we can intervene more efficiently, and safer, with T cell leukemia in future treatment programs in the clinic. To learn more, please visit our lab online.