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University of North Carolina, Lineberger CCC
Novel Approaches to Target PRC2 Enzymatic Complexes for the Treatment of Hematopoietic Malignancies
Enzymes that modify chromatin (the physiological form of DNA) are commonly found hyper-activated among lymphoma and myeloma. Novel therapeutics needs to be developed for treating these currently incurable malignancies. We investigate the mechanisms for their hyperactivities and develop new ways for their inhibition as novel cancer therapeutic inventions.