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Assistant Professor of Medicine
Washington University St. Louis
Integrative Epigenomics: The Consequences of Kdm6a Inactivation on Chromatin Accessibility and DNA Methylation in Hematopoiesis
We will determine if mutations in the gene, KDM6A, which are present in a wide variety of human cancers, are also associated with specific modifications of DNA (DNA methylation) and DNA structure. These associated changes may explain how KDM6A mutations contribute to carcinogenesis and have significant therapeutic implications.