Birgit Knoechel, MD, PhD

knoechel

Dana-Farber Cancer Institute
Enhancer rewiring in drug resistant T-ALL and its therapeutic implications

T-cell acute lymphoblastic leukemia (T-ALL) is a disease that affects children and young adults, for which outcome has remained poor, often due to rapid development of resistance to existing therapies. We propose to determine the epigenetic alterations responsible for drug resistance in T-ALL, and develop strategies for their therapeutic targeting.